最近の主な著書・論文等
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著書

-専門書-
Ohyama T. ed.: DNA Conformation and Transcription. Springer (New York), 2005 出版サイト

Bernstein H. and Bernstein C. ed. : Meiosis. InTech,2013 出版サイト

大山隆、東中川徹 共著:新・生命科学シリーズ エピジェネティクス  裳華房(東京)、2016 出版サイト

-教科書-

大山隆 監修:ベーシックマスター生化学 オーム社(東京)、2008 出版サイト 

東中川徹、大山隆、清水光弘 編集:ベーシックマスター分子生物学(改訂2版) オーム社(東京)、2013 出版サイト



原著論文

Yu, M. , Arai, N., Ochiai, T., Ohyama, T.
Expression and function of an S1-type nuclease in the digestive fluid of a sundew Drosera adelae. Ann. Bot. 131, 335-346 (2023)
Equal contribution
Annals of Botany誌(131巻2号)表紙になりました。

Yamamoto, Y., Miura, O., Ohyama, T.
Cruciform formable sequences within Pou5f1 enhancer are indispensable for mouse ES cell integrity. Int. J. Mol. Sci. 22, 3399 (2021)

Arai, N., Ohno, Y., Jumyo, S., Hamaji, Y. and Ohyama, T.
Organ-specific expression and epigenetic traits of genes encoding digestive enzymes in the lance-leaf sundew (Drosera adelae). J. Exp. Bot. 72, 1946-1961 (2021)

*早稲田大学からプレスリリースされました。

Journal of Experimental Botany誌(72巻5号)表紙になりました。

Miura, O., Ogake, T., Yoneyama, H., Kikuchi, Y. and Ohyama, T.
A strong structural correlation between short inverted repeat sequences and the polyadenylation signal in yeast and nucleosome exclusion by these inverted repeats. Curr. Genet. 65, 575-590 (2019)

Miura, O., Ogake, T. and Ohyama, T.
Requirement or exclusion of inverted repeat sequences with cruciform-forming potential in Escherichia coli revealed by genome-wide analyses. Curr. Genet. 64, 945-958 (2018)

Tanase, J., Yokoo, T., Matsumura, Y., Kinoshita, M., Kikuchi, Y., Suemori, H. and Ohyama, T.
Magnesium chloride and polyamine can differentiate mouse embryonic stem cells into trophectoderm or endoderm. Biochem. Biophys. Res. Commun. 482, 764-770 (2017)

Arai, N., Nishimura, E., Kikuchi, Y. and Ohyama, T.
Functional analyses of carnivorous plant-specific amino acid residues in S-like ribonucleases. Biochem. Biophys. Res. Commun. 465, 108-112 (2015)

Nishimura, E., Jumyo, S., Arai, N., Kanna, K., Kume, M., Nishikawa, J., Tanase, J. and Ohyama, T.
Structural and functional characteristics of S-like ribonucleases from carnivorous plants. Planta 240, 147-159 (2014)

Udagawa, K. and Ohyama, T.
Positions of pluripotency genes and hepatocyte-specific genes in the nucleus before and after mouse ES cell differentiation. Genet. Mol. Res. 13, 1979-1988 (2014)

Nishikawa, J. and Ohyama, T.
Selective association between nucleosomes with identical DNA sequences. Nucleic Acids Res. 41, 1544-1554 (2013)

Shimooka, Y., Nishikawa, J. and Ohyama, T.
Most methylation-susceptible DNA sequences in human embryonic stem cells undergo a change in conformation or flexibility upon methylation. Biochemistry 52, 1344-1353 (2013)

Nishimura, E., Kawahara, M., Kodaira, R., Kume, M., Arai, N., Nishikawa, J. and Ohyama, T.
S-like ribonuclease gene expression in carnivorous plants. Planta 238, 955-967 (2013)

Kimura, H., Shimooka, Y., Nishikawa, J., Miura, O., Sugiyama, S., Yamada, S. and Ohyama, T. 
The genome folding mechanism in yeast. J. Biochemistry 154, 137-147(2013) *2014年度JB論文賞*

Kimura, H., Kageyama, D., Furuya, M., Sugiyama, S., Murata, N. and Ohyama, T.
Regions with Unusually High Flexibility Occur Frequently in Human Genomic DNA. Biosci. Biotechnol. Biochem. 77, 612-617 (2013)

Udagawa, K., Kimura, H., Tanabe, H. and Ohyama, T. 
Nuclear localization of reporter genes activated by curved DNA. J. Biosci. Bioeng. 113, 431-437 (2012)

Tanase, J., Mitani, T., Udagawa, K., Nishikawa, J. and Ohyama, T. 
Competence of an artificial bent DNA as a transcriptional activator in mouse ES cells. Mol. Biol. Rep. 38, 37-47 (2011)

Tanase, J., Morohashi, N., Fujita, M., Nishikawa, J., Shimizu, M. and Ohyama, T.  
Highly efficient chromatin transcription induced by superhelically curved DNA segments: the underlying mechanism revealed by a yeast system. Biochemistry 49, 2351–2358 (2010)

Inoue, S., Sugiyama, S., Travers, A.A. and Ohyama, T. 
Self-assembly of double-stranded DNA molecules at nanomolar concentrations. Biochemistry 46, 164-171 (2007)

Sumida, N., Nishikawa, J., Kishi, H., Amano, M., Furuya, T., Sonobe, H. and Ohyama, T.
A designed curved DNA segment that is a remarkable activator of eukaryotic transcription. FEBS J. 273, 5691-5702 (2006)

Fukue, Y., Sumida, N., Tanase, J. and Ohyama, T.
A highly distinctive mechanical property found in the majority of human promoters and its transcriptional relevance. Nucleic Acids Res. 33, 3821-3827 (2005)

Okabe, T., Iwakiri, Y., Mori, H., Ogawa, T. and Ohyama, T.
An S-like ribonuclease gene is used to generate a trap-leaf enzyme in the carnivorous plant Drosera adelae. FEBS Lett. 579, 5729-5733 (2005)

Fukue, Y., Sumida, N., Nishikawa, J. and Ohyama, T.
Core promoter elements of eukaryotic genes have a highly distinctive mechanical property. Nucleic Acids Res. 32, 5834-5840 (2004)

Nishikawa, J., Amano, M., Fukue, Y., Tanaka, S., Kishi, H., Hirota, Y., Yoda, K. and Ohyama, T.
Left-handedly curved DNA regulates accessibility to cis-DNA elements in chromatin. Nucleic Acids Res. 31, 6651-6662 (2003)



総説

Ohyama, T.
New aspects of magnesium function: A key regulator in nucleosome self-assembly, chromatin folding and phase separation. Int. J. Mol. Sci. 20, 4232 (2019); doi:10.3390/ijms20174232.

Nishikawa, J., Shimooka, Y. and Ohyama, T.
Intrinsic homology-sensing and assembling property of chromatin fiber. In Bernstein, H. and Bernstein, C. (eds.), Meiosis. InTech (2013), ISBN 978-953-51-1197-9

大山隆, 木村元, 下岡保俊
ゲノムDNAはいかにして折り畳まれるか—DNA物性とゲノム収納—. 実験医学増刊号「細胞核—遺伝情報制御と疾患」 27, 2715-2722 (2009)

大山隆
DNAの高次構造と物理的特性に印された遺伝情報.  蛋白質核酸酵素  53, 1-11 (2008)

Ohyama, T.
Regulation of chromatin structure by curved DNA: how activator binding sites become accessible. In Nagata, K. and Takeyasu, K. (eds.), Nuclear Dynamics-Molecular Biology and Visualization of the Nucleus. Springer-Verlag (Tokyo), 227-238 (2007)

Ohyama, T., Sumida, N., Tanase, J, Inoue, S. and Okabe, T.
Genetic information carried in DNA conformation and properties. In Kiyama, R. and Shimizu, M. (eds.), DNA Structure, Chromatin and Gene Expression. Transworld Research Network (Kerala), 71-84 (2006)

Asayama, M. and Ohyama, T.
Curved DNA and prokaryotic promoters: a mechanism for activation of transcription. In Ohyama, T. (ed.), DNA Conformation and Transcription. Springer (New York), 37-51 (2005)

Ohyama, T.
Curved DNA and transcription in eukaryotes. In Ohyama, T. (ed.), DNA Conformation and Transcription. Springer (New York), 66-74 (2005)

Ohyama, T.
The role of unusual DNA structures in chromatin organization for transcription. In Ohyama, T. (ed.), DNA Conformation and Transcription. Springer (New York), 177-188 (2005)


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